Pregabalin is mainly excreted unchanged by the kidneys. The average T1/2 is 6.3 h. Blood plasma clearance and renal clearance of pregabalin are directly proportional to CK.
Pharmacokinetics of pregabalin when used in the range of recommended daily doses is linear, interindividual variability is low (less than 20%).
Considering that pregabalin is mostly excreted by the kidneys.
In addition, pregabalin is effectively removed from the blood plasma by hemodialysis.
No special pharmacokinetic studies have been performed in patients with hepatic impairment.
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